| ATP Memphis | 02/13 19:30 | 25 | Yoshihito Nishioka v Garcia-Lopez, Guillermo | 6-4,6-4 | |
| ATP - Montpellier | 02/06 20:15 | 25 | [84] Brown, Dustin v Garcia-Lopez, Guillermo [99] | 7-6,6-3 | |
| Open d'Australie, Melbourne, Australie | 01/16 01:25 | 23 | [74] Garcia-Lopez, Guillermo v Zverev, Mischa [50] | 3-6,6-7,4-6 | |
| ATP - Auckland | 01/09 23:30 | 25 | [89] Harrison, Ryan v Garcia-Lopez, Guillermo [73] | 6-1,6-2 | |
| ATP Chennai | 01/03 11:35 | 25 | Bedene, Aljaz v Garcia-Lopez, Guillermo | 6-3,6-3 | |
| ATP Vienna | 10/25 13:45 | 25 | [76] Garcia-Lopez, Guillermo v Simon, Gilles [24] | 4-6,5-7 | |
| Antwerp, Belgium | 10/18 10:00 | 25 | Jozef Kovalik v Garcia-Lopez, Guillermo | 6-3,6-3 | |
| Shanghai, Chine | 10/11 05:00 | 24 | [75] Garcia-Lopez, Guillermo v Lorenzi, Paolo [37] | 7-5,6-7,3-6 | |
| Pékin, Chine | 10/03 09:45 | 25 | [73] Garcia-Lopez, Guillermo v Kyle Edmund [54] | 3-6,2-6 | |
| ATP Shenzhen | 09/27 06:00 | 25 | Harrison, Ryan v Garcia-Lopez, Guillermo | 7-5,6-4 | |
| Metz, France | 09/22 12:10 | 26 | Simon, Gilles v Garcia-Lopez, Guillermo | 6-7,6-3,6-4 | |
| Metz, France | 09/20 14:20 | 25 | Damir Dzumhur v Garcia-Lopez, Guillermo | 7-5,2-6,1-6 | |
| US Open, New York, USA | 08/29 22:30 | 23 | Garcia-Lopez, Guillermo v Bautista-Agut, Roberto | 5-7,1-6,7-6,6-7 | |
| Umag, Croatia | 07/19 15:00 | 25 | Gastao Elias v Garcia-Lopez, Guillermo | 6-1,6-2 | |
| Hamburg, Germany | 07/15 10:40 | 27 | Garcia-Lopez, Guillermo v Robert, Stephane | 6-7,6-4,3-6 | |
| Hamburg, Germany | 07/14 11:40 | 26 | Garcia-Lopez, Guillermo v Zemlja, Grega | 6-2,6-2 | |
| Hamburg, Germany | 07/12 11:00 | 25 | Garcia-Lopez, Guillermo v Kenny de Schepper | 5-7,6-2,7-6 | |
| Wimbledon, London, Great Britain | 06/27 13:45 | 23 | Seppi, Andreas v Garcia-Lopez, Guillermo | 6-2,6-4,6-0 | |
| French Open, Paris, France | 05/26 10:20 | 24 | Garcia-Lopez, Guillermo v Dominic Thiem | 5-7,4-6,6-7 | |
| French Open, Paris, France | 05/24 12:05 | 23 | de Bakker, Thiemo v Garcia-Lopez, Guillermo | 4-6,4-6,7-5,6-7 | |
| Geneva, Switzerland | 05/19 13:15 | 27 | Garcia-Lopez, Guillermo v FERRER D. | 2-6,2-6 | |
| Geneva, Switzerland | 05/18 11:40 | 26 | Garcia-Lopez, Guillermo v Ram, Rajeev | 6-4,7-6 | |
| Geneva, Switzerland | 05/16 10:00 | 25 | Querrey, Sam v Garcia-Lopez, Guillermo | 6-7,4-6 | |
| ATP - Madrid | 05/02 21:10 | 24 | Garcia-Lopez, Guillermo v FERRER D. | 6-3,1-6,2-6 | |
| ATP - Monte-Carlo | 04/12 13:25 | 25 | Federer, Roger v Garcia-Lopez, Guillermo | 6-3,6-4 | |
| ATP - Monte-Carlo | 04/11 09:00 | 24 | Bellucci, Thomaz v Garcia-Lopez, Guillermo | 5-7,1-6 | |
| ATP - Marrakech | 04/08 16:40 | 27 | Garcia-Lopez, Guillermo v Jiri Vesely | 4-6,6-7 | |
| ATP - Marrakech | 04/07 15:00 | 26 | Garcia-Lopez, Guillermo v Almagro, Nicolas | 1-6,6-3,6-4 | |
| ATP - Miami | 03/25 15:00 | 24 | Garcia-Lopez, Guillermo v Lucas Pouille | 2-6,4-6 | |
| Challenger Shanghai | 10/12 05:30 | 24 | Bautista-Agut, Roberto v Garcia-Lopez, Guillermo | 6-2,6-3 |