| ATP - Barcelone | 04/20 10:10 | 45 | [117] Garcia-Lopez, Guillermo v Berlocq, Carlos [179] | 6-4,6-3 | |
| ATP - Barcelone | 04/20 09:20 | 45 | Garcia-Lopez, Guillermo v Andujar, Pablo | Cancelled | |
| Tunis, Tunisia | 04/17 10:45 | 25 | [221] Joao Domingues v Garcia-Lopez, Guillermo [117] | 6-4,5-7,6-4 | |
| ATP - Houston | 04/11 18:35 | 26 | [71] Querrey, Sam v Garcia-Lopez, Guillermo [115] | 6-4,6-3 | |
| ATP - Houston | 04/09 19:20 | 25 | [115] Garcia-Lopez, Guillermo v Noah Rubin [144] | 6-7,6-3,6-3 | |
| Alicante, Spain | 04/04 09:30 | 26 | [113] Garcia-Lopez, Guillermo v Carlos Taberner [301] | 7-6,1-6,4-6 | |
| Alicante, Spain | 04/02 17:10 | 25 | [113] Garcia-Lopez, Guillermo v Pedro Cachin [236] | 6-0,6-4 | |
| Marbella, Spain | 03/28 13:35 | 26 | [158] Pedro Martinez v Garcia-Lopez, Guillermo [112] | 3-6,6-3,6-1 | |
| Marbella, Spain | 03/26 11:45 | 25 | [187] Lopez Perez v Garcia-Lopez, Guillermo [112] | 6-4,5-7,5-7 | |
| Challenger - Lille | 03/19 17:50 | 25 | [112] Garcia-Lopez, Guillermo v Pavlasek, Adam [222] | 5-7,6-7 | |
| ATP - Acapulco | 02/27 00:30 | 25 | [57] Querrey, Sam v Garcia-Lopez, Guillermo [103] | 6-3,6-2 | |
| ATP - Acapulco | 02/25 01:00 | 164 | [101] Garcia-Lopez, Guillermo v Granollers, Marcel [111] | 4-6,6-3,1-6 | |
| ATP - Acapulco | 02/24 01:20 | 64 | [101] Garcia-Lopez, Guillermo v Roberto Cid Subervi [246] | 6-3,6-3 | |
| ATP - Delray Beach | 02/21 23:30 | 26 | [101] Garcia-Lopez, Guillermo v Mackenzie McDonald [84] | 5-7,4-6 | |
| ATP - Delray Beach | 02/19 16:00 | 25 | [101] Garcia-Lopez, Guillermo v Donaldson, Jared [120] | 2-6,6-3,6-3 | |
| New York, USA | 02/15 21:50 | 27 | [102] Garcia-Lopez, Guillermo v Opelka, Reilly [89] | 3-6,4-6 | |
| New York, USA | 02/14 16:00 | 26 | [37] John Millman v Garcia-Lopez, Guillermo [102] | 6-7,6-1,4-6 | |
| New York, USA | 02/12 18:15 | 25 | [102] Garcia-Lopez, Guillermo v Alexei Popyrin [123] | 7-6,6-3 | |
| New York, USA | 02/12 17:20 | - | Garcia-Lopez, Guillermo v Klahn, Bradley | Cancelled | |
| Open d'Australie | 01/14 01:25 | 23 | [100] Garcia-Lopez, Guillermo v Haase, Robin [58] | 5-7,4-6,5-7 | |
| Sydney, Australia | 01/09 02:00 | 26 | [19] Diego Schwartzman v Garcia-Lopez, Guillermo [101] | 6-2,6-3 | |
| Sydney, Australia | 01/08 00:00 | 25 | [62] Denis Kudla v Garcia-Lopez, Guillermo [101] | 5-7,4-6 | |
| Sydney, Australia | 01/06 07:05 | 164 | [105] Garcia-Lopez, Guillermo v Alex Bolt [154] | 7-6,6-3 | |
| Sydney, Australia | 01/05 03:20 | 64 | [67] Bedene, Aljaz v Garcia-Lopez, Guillermo [105] | 7-5,4-6,6-7 | |
| ATP - Doha | 01/02 12:30 | 26 | [105] Garcia-Lopez, Guillermo v Bautista-Agut, Roberto [24] | 1-6,4-6 | |
| ATP - Doha | 01/01 14:35 | 25 | Mubarak Shannan Zayid v Garcia-Lopez, Guillermo | 1-6,3-6 | |
| ATP - Doha | 12/30 12:30 | 164 | [105] Garcia-Lopez, Guillermo v Baghdatis, Marcos [125] | 4-6,6-2,6-4 | |
| ATP - Doha | 12/29 08:00 | 64 | [105] Garcia-Lopez, Guillermo v Ward, James [190] | 7-6,6-2 | |
| ATP - Doha | 12/29 08:00 | 64 | [105] Garcia-Lopez, Guillermo v Maden, Yannick [127] | Cancelled | |
| Challenger Bratislava | 11/07 11:20 | 26 | [104] Garcia-Lopez, Guillermo v Sebastian Ofner [203] | 5-7,4-6 |