| US Open, New York, USA | 08/27 17:25 | 23 | [14] Isner, John v Garcia-Lopez, Guillermo [165] | 6-3,6-4,6-4 | |
| US Open, New York, USA | 08/23 20:25 | 46 | [201] Constant Lestienne v Garcia-Lopez, Guillermo [166] | 4-6,4-6 | |
| US Open, New York, USA | 08/22 17:10 | 45 | [195] Noah Rubin v Garcia-Lopez, Guillermo [166] | 1-6,6-7 | |
| US Open, New York, USA | 08/20 15:00 | 44 | [166] Garcia-Lopez, Guillermo v Lorenzo Giustino [128] | 3-6,7-5,6-2 | |
| Augsbourg, Allemagne | 08/09 10:00 | 27 | [313] Lenz, Julian v Garcia-Lopez, Guillermo [161] | 7-6,3-6,7-5 | |
| Augsbourg, Allemagne | 08/08 10:15 | 26 | [347] Carlos Taberner v Garcia-Lopez, Guillermo [161] | 3-6,7-5,2-6 | |
| Augsbourg, Allemagne | 08/06 10:35 | 25 | [278] Renzo Olivo v Garcia-Lopez, Guillermo [161] | 6-7,4-6 | |
| Kitzbuhel, Austria | 07/30 09:00 | 25 | [326] Jozef Kovalik v Garcia-Lopez, Guillermo [158] | 6-7,6-2,6-3 | |
| Kitzbuhel, Austria | 07/28 10:15 | 164 | [163] Garcia-Lopez, Guillermo v Elliot Benchetrit [220] | 6-4,7-6 | |
| Kitzbuhel, Austria | 07/27 11:15 | 64 | [163] Garcia-Lopez, Guillermo v Zelenay, Igor [65] | 6-3,6-4 | |
| Gstaad, Switzerland | 07/21 11:05 | 164 | [151] Baldi, Filippo v Garcia-Lopez, Guillermo [162] | 4-6,7-6,6-2 | |
| Gstaad, Switzerland | 07/20 13:00 | 64 | [313] Escobar, Gonzalo v Garcia-Lopez, Guillermo [162] | 1-6,2-6 | |
| Challenger Perugia | 07/14 19:00 | 29 | [75] Delbonis, Federico v Garcia-Lopez, Guillermo [164] | 6-0,1-6,7-6 | |
| Challenger Perugia | 07/13 19:15 | 28 | [99] Albert Ramos-Vinolas v Garcia-Lopez, Guillermo [164] | 6-4,6-7,2-6 | |
| Challenger Perugia | 07/12 11:00 | 27 | [164] Garcia-Lopez, Guillermo v Quinzi, Gianluigi [262] | 6-3,1-6,7-6 | |
| Challenger Perugia | 07/11 10:30 | 26 | [107] Sousa, Pedro v Garcia-Lopez, Guillermo [164] | 6-7,2-6 | |
| Challenger Perugia | 07/09 17:00 | 25 | Aldin Setkic v Garcia-Lopez, Guillermo | Walkover | |
| Wimbledon, London, Great Britain | 06/26 10:00 | 45 | [152] Garcia-Lopez, Guillermo v Lukas Rosol [130] | 5-7,6-3,6-8 | |
| Wimbledon, London, Great Britain | 06/24 10:00 | 44 | [152] Garcia-Lopez, Guillermo v Myneni, Saketh [249] | 6-4,4-6,7-5 | |
| Ilkley, Great Britain | 06/17 13:00 | 24 | [154] Garcia-Lopez, Guillermo v Sugita, Yuichi [205] | 1-6,6-7 | |
| Prostejov, Czech Republic | 06/05 11:00 | 26 | [136] Garcia-Lopez, Guillermo v Arevalo-Gonzalez, Marcelo [307] | 3-6,6-4,1-6 | |
| Prostejov, Czech Republic | 06/03 10:05 | 25 | Garcia-Lopez, Guillermo v Karim-Mohamed Maamoun | 6-4,6-2 | |
| French Open, Paris, France | 05/28 09:00 | 23 | [136] Garcia-Lopez, Guillermo v Delbonis, Federico [75] | 1-6,6-3,3-6,2-6 | |
| French Open, Paris, France | 05/23 13:15 | 46 | [123] Garcia-Lopez, Guillermo v Oscar Otte [145] | 3-6,6-4,6-0 | |
| French Open, Paris, France | 05/22 11:50 | 45 | [123] Garcia-Lopez, Guillermo v Krstin, Pedja [209] | 4-6,6-3,6-4 | |
| French Open, Paris, France | 05/20 12:10 | 44 | [123] Garcia-Lopez, Guillermo v Smyczek, Tim [228] | 6-1,6-4 | |
| Challenger Heilbronn | 05/16 09:30 | 26 | [122] Garcia-Lopez, Guillermo v Troicki, Viktor [259] | 4-6,4-6 | |
| Challenger Heilbronn | 05/15 11:35 | 25 | Garcia-Lopez, Guillermo v Daniel Altmaier | 6-3,6-3 | |
| Challenger - Aix en Provence | 05/08 10:30 | 25 | [123] Garcia-Lopez, Guillermo v Enzo Couacaud [238] | 6-7,4-6 | |
| ATP - Barcelone | 04/21 10:15 | 64 | [74] Delbonis, Federico v Garcia-Lopez, Guillermo [117] | 6-3,6-0 |