| ATP Rome Qual | 05/13 10:55 | 46 | Baldi, Filippo v Garcia-Lopez, Guillermo | 4-6,6-4,7-6 | |
| ATP Rome Qual | 05/12 11:25 | 45 | Bemelmans, Ruben v Garcia-Lopez, Guillermo | 3-6,1-6 | |
| ATP - Madrid | 05/08 16:15 | 24 | [69] Garcia-Lopez, Guillermo v Harrison, Ryan [59] | 4-6,6-7 | |
| ATP - Barcelone | 04/26 14:15 | 26 | [1] Rafael Nadal v Garcia-Lopez, Guillermo [69] | 6-1,6-3 | |
| ATP - Barcelone | 04/25 09:00 | 25 | [69] Garcia-Lopez, Guillermo v Kei Nishikori [22] | Retired | |
| ATP - Barcelone | 04/23 13:05 | 24 | [42] Sugita, Yuichi v Garcia-Lopez, Guillermo [69] | 6-7,6-7 | |
| ATP - Monte-Carlo | 04/18 12:40 | 25 | [68] Garcia-Lopez, Guillermo v Seppi, Andreas [62] | 6-4,3-6,5-7 | |
| ATP Monte Carlo Qual | 04/15 09:00 | 46 | [67] Garcia-Lopez, Guillermo v Marco Cecchinato [100] | 4-6,2-6 | |
| ATP Monte Carlo Qual | 04/14 11:20 | 45 | [67] Garcia-Lopez, Guillermo v Lorenzo Sonego [159] | 6-4,6-3 | |
| ATP - Marrakech | 04/11 17:35 | 26 | [67] Garcia-Lopez, Guillermo v Richard Gasquet [38] | 2-6,4-6 | |
| ATP - Marrakech | 04/10 11:50 | 25 | [135] Calvin Hemery v Garcia-Lopez, Guillermo [67] | 2-6,2-6 | |
| ATP - Miami | 03/24 18:50 | 24 | [69] Garcia-Lopez, Guillermo v Verdasco, Fernando [39] | 6-4,0-6,2-6 | |
| ATP - Miami | 03/22 17:40 | 23 | [69] Garcia-Lopez, Guillermo v Tennys Sandgren [58] | 7-6,7-6 | |
| Sao Paulo, Brazil | 03/02 18:45 | 27 | Garcia-Lopez, Guillermo v Fabio Fognini | 4-6,2-6 | |
| Sao Paulo, Brazil | 02/28 17:40 | 26 | Delbonis, Federico v Garcia-Lopez, Guillermo | 6-7,6-4,4-6 | |
| Sao Paulo, Brazil | 02/26 15:30 | 25 | Gerald Melzer v Garcia-Lopez, Guillermo | 4-6,6-3,3-6 | |
| ATP - Rio De Janeiro | 02/19 19:30 | 25 | Garcia-Lopez, Guillermo v Nicolas Jarry | 3-6,6-7 | |
| ATP - Buenos Aires | 02/16 17:00 | 27 | Delbonis, Federico v Garcia-Lopez, Guillermo | 6-3,7-5 | |
| ATP - Buenos Aires | 02/15 17:00 | 26 | Garcia-Lopez, Guillermo v Carreno-Busta, Pablo | 7-6,1-6,7-6 | |
| ATP - Buenos Aires | 02/12 21:45 | 25 | Berlocq, Carlos v Garcia-Lopez, Guillermo | 3-6,3-6 | |
| ATP - Montpellier | 02/05 19:35 | 25 | Andrey Rublev v Garcia-Lopez, Guillermo | 6-4,6-4 | |
| Open d'Australie | 01/18 02:00 | 24 | BERDYCH T. v Garcia-Lopez, Guillermo | 6-3,2-6,6-2,6-3 | |
| Open d'Australie | 01/16 06:15 | 23 | Garcia-Lopez, Guillermo v Benoit Paire | 6-0,6-7,6-1,6-4 | |
| Challenger Canberra | 01/11 02:00 | 27 | Seppi, Andreas v Garcia-Lopez, Guillermo | 6-3,6-4 | |
| Challenger Canberra | 01/10 06:15 | 26 | Geoffrey Blancaneaux v Garcia-Lopez, Guillermo | 5-7,4-6 | |
| Challenger Canberra | 01/09 00:00 | 25 | Bangoura, Sekou v Garcia-Lopez, Guillermo | 3-6,4-6 | |
| ATP - Doha | 01/02 12:30 | 25 | Lopez, Feliciano v Garcia-Lopez, Guillermo | 6-4,5-7,7-6 | |
| ATP Paris Qual | 10/29 12:45 | 46 | [81] Garcia-Lopez, Guillermo v Chardy, Jérémy [87] | 3-6,4-6 | |
| ATP Paris Qual | 10/28 16:05 | 45 | [50] Donaldson, Jared v Garcia-Lopez, Guillermo [81] | 5-7,7-6,4-6 | |
| ATP Vienna | 10/26 12:00 | 26 | Garcia-Lopez, Guillermo v Lucas Pouille | 3-6,6-7 |