| Open d'Australie | 01/15 01:15 | 23 | Delbonis, Federico v Muller, Gilles | 5-7,4-6,3-6 | |
| Sydney, Australia | 01/11 08:00 | 27 | Benoit Paire v Muller, Gilles | 6-4,6-4 | |
| Sydney, Australia | 01/10 09:50 | 26 | John Millman v Muller, Gilles | 6-7,4-6 | |
| ATP Brisbane | 01/02 02:55 | 25 | Chung, Hyeon v Muller, Gilles | 6-3,7-6 | |
| Metz, France | 09/21 10:00 | 26 | [64] Nikoloz Basilashvili v Muller, Gilles [23] | 6-4,6-4 | |
| US Open, New York, USA | 08/30 20:50 | 24 | [40] Lorenzi, Paolo v Muller, Gilles [23] | 6-7,6-3,7-6,6-3 | |
| US Open, New York, USA | 08/28 19:25 | 23 | [146] Bernard Tomic v Muller, Gilles [23] | 6-3,3-6,4-6,4-6 | |
| Cincinnati, USA | 08/16 20:10 | 25 | Albert Ramos-Vinolas v Muller, Gilles | 5-7,6-4,6-4 | |
| Cincinnati, USA | 08/13 18:40 | 24 | [44] Harrison, Ryan v Muller, Gilles [21] | 4-6,7-5,6-7 | |
| Washington, USA | 08/04 03:25 | 26 | [225] Tommy Paul v Muller, Gilles [21] | 6-7,6-4,6-3 | |
| Washington, USA | 08/02 21:55 | 25 | Tursunov, Dmitry v Muller, Gilles | 1-6,2-6 | |
| Atlanta, USA | 07/29 19:00 | 28 | [22] Muller, Gilles v Isner, John [20] | 4-6,2-6 | |
| Atlanta, USA | 07/28 16:00 | 27 | [291] Tommy Paul v Muller, Gilles [22] | 3-6,1-6 | |
| Atlanta, USA | 07/26 18:45 | 26 | [134] Quentin Halys v Muller, Gilles [22] | 4-6,7-6,3-6 | |
| Wimbledon, London, Great Britain | 07/12 12:00 | 27 | [26] Muller, Gilles v Marin Cilic [6] | 6-3,6-7,5-7,7-5,1-6 | |
| Wimbledon, London, Great Britain | 07/10 14:30 | 26 | [2] Rafael Nadal v Muller, Gilles [26] | 3-6,4-6,6-3,6-4,13-15 | |
| Wimbledon, London, Great Britain | 07/07 10:30 | 25 | [58] Bedene, Aljaz v Muller, Gilles [26] | 6-7,5-7,4-6 | |
| Wimbledon, London, Great Britain | 07/05 10:30 | 24 | [215] Lukas Rosol v Muller, Gilles [26] | 5-7,7-6,6-4,3-6,7-9 | |
| Wimbledon, London, Great Britain | 07/03 16:05 | 23 | [109] Marton Fucsovics v Muller, Gilles [26] | 5-7,4-6,2-6 | |
| London, Great Britain | 06/24 12:15 | 28 | [26] Muller, Gilles v Marin Cilic [7] | 3-6,7-5,4-6 | |
| London, Great Britain | 06/23 11:00 | 27 | [28] Querrey, Sam v Muller, Gilles [26] | 4-6,6-7 | |
| London, Great Britain | 06/21 12:25 | 26 | [26] Muller, Gilles v Tsonga, Jo-Wilfried [10] | 6-4,6-4 | |
| London, Great Britain | 06/20 16:35 | 25 | [51] Nikoloz Basilashvili v Muller, Gilles [26] | 4-6,7-6,4-6 | |
| ATP Den Bosch | 06/18 12:30 | 29 | [24] Karlovic, Ivo v Muller, Gilles [28] | 6-7,6-7 | |
| ATP Den Bosch | 06/17 13:20 | 28 | [28] Muller, Gilles v Alexander Zverev [10] | 7-6,6-2 | |
| ATP Den Bosch | 06/16 09:00 | 27 | [59] Bedene, Aljaz v Muller, Gilles [28] | 3-6,6-3,4-6 | |
| ATP Den Bosch | 06/14 13:15 | 26 | [76] Seppi, Andreas v Muller, Gilles [28] | 6-7,4-6 | |
| French Open, Paris, France | 05/28 09:00 | 23 | [153] Garcia-Lopez, Guillermo v Muller, Gilles [27] | 7-6,6-7,6-2,6-2 | |
| ATP - Madrid | 05/10 10:00 | 25 | [6] Milos Raonic v Muller, Gilles [26] | 6-4,6-4 | |
| ATP - Madrid | 05/09 14:20 | 24 | [403] HAAS T. v Muller, Gilles [26] | 4-6,6-7 |