Face à face
| Première division, Playoffs | 2021/10/31 19:00 | Penarol v Club Nacional de Footbal | D | 0-0 |
| Copa Sudamericana | 2021/07/23 00:30 | Penarol v Club Nacional de Footbal | W | 0-1 |
| Copa Sudamericana | 2021/07/16 00:30 | Club Nacional de Footbal v Penarol | L | 1-2 |
| Uruguay - Tournoi d'ouverture | 2021/07/04 19:00 | Club Nacional de Footbal v Penarol | W | 2-0 |
| Première division, Playoffs | 2021/02/03 21:30 | Penarol v Club Nacional de Footbal | D | 0-0 |
| Uruguay - Torneo Intermedio | 2020/12/13 20:30 | Penarol v Club Nacional de Footbal | L | 3-2 |
| Uruguay - Tournoi d'ouverture | 2020/08/09 18:00 | Club Nacional de Footbal v Penarol | D | 1-1 |
| Primera Division, Season First Place | 2019/12/15 20:00 | Club Nacional de Footbal v Penarol | W | 1-0 |
Home History
| Matchs amicaux | 2022/01/19 22:15 | Club Nacional de Footbal v Barracas Central | L | 1-2 |
| Matchs amicaux | 2022/01/18 00:30 | Club Nacional de Footbal v Nublense | W | 6-4 |
| Première division, Playoffs | 2021/12/04 20:00 | Club Nacional de Footbal v CA River Plate | W | 4-2 |
| Première division, Playoffs | 2021/11/26 19:30 | Liverpool Montevideo v Club Nacional de Footbal | D | 2-2 |
| Première division, Playoffs | 2021/11/19 00:45 | Club Nacional de Footbal v Cerrito | W | 1-0 |
| Première division, Playoffs | 2021/11/13 19:30 | Deportivo Maldonado v Club Nacional de Footbal | L | 1-0 |
| Première division, Playoffs | 2021/11/07 00:45 | Villa Espanola v Club Nacional de Footbal | W | 1-2 |
| Première division, Playoffs | 2021/11/04 00:00 | Club Nacional de Footbal v Torque | W | 2-0 |
Away History
| Amérique - Matchs amicaux | 2022/01/20 00:30 | Penarol v Nublense | W | 1-0 |
| Matchs amicaux | 2022/01/17 22:15 | Penarol v Barracas Central | W | 4-0 |
| Première division, Playoffs | 2021/12/07 23:30 | Plaza Colonia v Penarol | W | 8-9 |
| Première division, Playoffs | 2021/12/04 20:00 | Penarol v IA Sud America | W | 3-1 |
| Première division, Playoffs | 2021/11/25 19:30 | Club Atlético Progreso v Penarol | D | 0-0 |
| Première division, Playoffs | 2021/11/23 00:45 | Penarol v Cerro Largo | D | 2-2 |
| Première division, Playoffs | 2021/11/14 19:30 | CA River Plate v Penarol | D | 1-1 |
| Première division, Playoffs | 2021/11/07 22:00 | Penarol v Liverpool Montevideo | W | 1-0 |
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