| St. Petersburg, Russia | 09/20 14:05 | 26 | [110] Youzhny, Mikhail v Bautista-Agut, Roberto [26] | 6-7,6-3,3-6 | |
| St. Petersburg, Russia | 09/19 16:00 | 25 | [78] Mirza Basic v Youzhny, Mikhail [110] | 6-7,4-6 | |
| US Open, New York, USA | 08/28 20:00 | 23 | [93] Baghdatis, Marcos v Youzhny, Mikhail [106] | Retired | |
| Toronto, Canada | 08/08 16:00 | 25 | [104] Youzhny, Mikhail v Haase, Robin [39] | 5-7,2-6 | |
| ATP Toronto Qual | 08/05 16:55 | 46 | Evgeny Donskoy v Youzhny, Mikhail | Walkover | |
| ATP Toronto Qual | 08/04 17:00 | 45 | Alexis Galarneau v Youzhny, Mikhail | 3-6,4-6 | |
| Washington, USA | 07/31 02:45 | 24 | [102] Youzhny, Mikhail v Noah Rubin [152] | 4-6,4-6 | |
| Atlanta, USA | 07/25 20:00 | 26 | [105] Youzhny, Mikhail v Zverev, Mischa [45] | 4-6,2-6 | |
| Atlanta, USA | 07/24 23:00 | 25 | Youzhny, Mikhail v Reinberg, Emil | 6-2,6-0 | |
| Challenger Astana | 07/18 10:40 | 26 | [105] Youzhny, Mikhail v Myneni, Saketh [357] | 6-3,4-6,3-6 | |
| Challenger Astana | 07/17 05:55 | 25 | [105] Youzhny, Mikhail v Gonzalez, Alejandro [313] | 6-3,2-6,7-5 | |
| Wimbledon, London, Great Britain | 07/02 12:50 | 23 | [112] Karlovic, Ivo v Youzhny, Mikhail [102] | 4-6,7-5,7-6,6-3 | |
| Antalya, Turquie | 06/25 15:05 | 25 | [94] Youzhny, Mikhail v Haase, Robin [43] | 6-7,7-6,4-6 | |
| ATP Antalya Qual | 06/24 11:00 | 164 | [94] Youzhny, Mikhail v Grigelis, Laurynas [263] | 6-7,6-4,6-2 | |
| ATP Antalya Qual | 06/23 13:10 | 64 | [94] Youzhny, Mikhail v Dancevic, Frank [314] | 7-6,6-1 | |
| ATP Halle | 06/18 15:50 | 25 | [7] Dominic Thiem v Youzhny, Mikhail [94] | 7-6,6-2 | |
| ATP Halle Qual | 06/17 10:50 | 164 | [80] Matteo Berrettini v Youzhny, Mikhail [93] | 3-6,6-7 | |
| ATP Halle Qual | 06/16 11:35 | 64 | [103] Bemelmans, Ruben v Youzhny, Mikhail [93] | 6-7,2-6 | |
| Stuttgart, Germany | 06/11 13:00 | 25 | [93] Youzhny, Mikhail v Zverev, Mischa [54] | 6-7,3-6 | |
| ATP Stuttgart Qual | 06/10 09:00 | 164 | [98] Youzhny, Mikhail v Egor Gerasimov [246] | 6-3,6-2 | |
| ATP Stuttgart Qual | 06/09 11:00 | 64 | [98] Youzhny, Mikhail v Guez, David [259] | 6-2,6-3 | |
| Surbiton, Great Britain | 06/04 13:30 | 25 | [98] Youzhny, Mikhail v King, Kevin [169] | 6-7,5-7 | |
| French Open, Paris, France | 05/28 13:05 | 23 | [63] Jaziri, Malek v Youzhny, Mikhail [98] | 2-6,6-2,6-2,3-6,6-2 | |
| ATP Rome Qual | 05/13 13:10 | 46 | [62] Jaziri, Malek v Youzhny, Mikhail [101] | 6-4,3-6,6-3 | |
| ATP Rome Qual | 05/12 15:35 | 45 | [101] Youzhny, Mikhail v Taylor Fritz [68] | 6-4,3-6,6-4 | |
| ATP Madrid Qual | 05/06 09:00 | 46 | [79] Delbonis, Federico v Youzhny, Mikhail [99] | 6-3,6-1 | |
| ATP Madrid Qual | 05/05 10:30 | 45 | [102] Matteo Berrettini v Youzhny, Mikhail [99] | 6-4,3-6,2-6 | |
| ATP Istanbul | 05/01 11:40 | 25 | [100] Fabbiano, Thomas v Youzhny, Mikhail [99] | 6-1,6-1 | |
| Budapest, Hongrie | 04/26 09:00 | 26 | [55] Seppi, Andreas v Youzhny, Mikhail [100] | 6-1,6-2 | |
| Budapest, Hongrie | 04/24 16:25 | 25 | [453] Zsombor Piros v Youzhny, Mikhail [100] | 3-6,3-6 |