Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Jimmy Rogers
| NCAAF | 2021/10/09 19:00 | Southern Illinois v South Dakota State | L | 42-41 |
| NCAAF | 2021/05/03 01:00 | Southern Illinois v South Dakota State | W | 26-31 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v Southern Illinois | W | 44-3 |
| NCAAF | 2019/10/05 19:00 | Southern Illinois v South Dakota State | W | 10-28 |
| NCAAF FCS | 2018/11/10 19:00 | South Dakota State v Southern Illinois | W | 57-38 |
| NCAAF | 2017/10/07 23:00 | South Dakota State v Southern Illinois | W | 49-14 |
| NCAAF | 2023/10/14 19:00 | Northern Iowa v South Dakota State | W | 6-41 |
| NCAAF | 2023/10/07 23:00 | South Dakota State v Illinois State | W | 40-21 |
| NCAAF | 2023/09/30 19:00 | North Dakota v South Dakota State | W | 21-42 |
| NCAAF | 2023/09/16 19:30 | Drake v South Dakota State | W | 7-70 |
| NCAAF | 2023/09/09 23:00 | Montana State v South Dakota State | W | 16-20 |
| NCAAF | 2023/09/01 00:00 | South Dakota State v Western Oregon Wolves | W | 45-7 |
| NCAAF | 2023/01/08 19:00 | DAKOTA DU NORD ETAT DU BISON v South Dakota State | W | 21-45 |
| NCAAF | 2022/12/17 21:00 | Montana State v South Dakota State | W | 18-39 |
| NCAAF | 2023/10/14 19:00 | Southern Illinois v Murray State | W | 27-6 |
| NCAAF | 2023/10/07 22:00 | Southern Illinois v Youngstown State | L | 3-31 |
| NCAAF | 2023/09/30 21:00 | Missouri State v Southern Illinois | W | 20-33 |
| NCAAF | 2023/09/16 23:00 | Southern Illinois v SE Missouri State | W | 26-25 |
| NCAAF | 2023/09/09 19:30 | Southern Illinois v Northern Illinois | W | 14-11 |
| NCAAF | 2023/09/02 23:00 | Austin Peay v Southern Illinois | W | 23-49 |
| NCAAF | 2022/11/19 17:00 | Southern Illinois v Youngstown State | L | 21-28 |
| NCAAF | 2022/11/12 19:00 | DAKOTA DU NORD ETAT DU BISON v Southern Illinois | L | 21-18 |