Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Ryan Beard
| NCAAF | 2022/10/08 19:00 | Southern Illinois v Missouri State | L | 38-21 |
| NCAAF | 2021/11/06 17:00 | Missouri State v Southern Illinois | W | 38-28 |
| NCAAF | 2021/03/27 19:00 | Southern Illinois v Missouri State | W | 27-30 |
| NCAAF | 2019/11/09 20:00 | Missouri State v Southern Illinois | L | 14-37 |
| NCAAF | 2018/10/27 19:00 | Missouri State v Southern Illinois | L | 35-49 |
| NCAAF | 2017/11/04 18:00 | Southern Illinois v Missouri State | W | 28-36 |
| NCAAF | 2023/09/23 19:00 | Dixie State Trailblazers v Missouri State | W | 14-59 |
| NCAAF | 2023/09/09 23:00 | Missouri State v UT Martin | L | 31-38 |
| NCAAF | 2023/09/02 00:00 | Missouri State v Kansas | L | 17-48 |
| NCAAF | 2022/11/19 18:00 | Missouri State v Indiana State | W | 24-7 |
| NCAAF | 2022/11/12 20:00 | Youngstown State v Missouri State | W | 22-25 |
| NCAAF | 2022/11/05 18:00 | Missouri State v South Dakota | L | 13-20 |
| NCAAF | 2022/10/29 19:00 | Western Illinois v Missouri State | W | 14-64 |
| NCAAF | 2022/10/22 21:00 | Missouri State v Northern Iowa | L | 20-41 |
| NCAAF | 2023/09/16 23:00 | Southern Illinois v SE Missouri State | W | 26-25 |
| NCAAF | 2023/09/09 19:30 | Southern Illinois v Northern Illinois | W | 14-11 |
| NCAAF | 2023/09/02 23:00 | Austin Peay v Southern Illinois | W | 23-49 |
| NCAAF | 2022/11/19 17:00 | Southern Illinois v Youngstown State | L | 21-28 |
| NCAAF | 2022/11/12 19:00 | DAKOTA DU NORD ETAT DU BISON v Southern Illinois | L | 21-18 |
| NCAAF | 2022/10/29 19:00 | Northern Iowa v Southern Illinois | L | 37-36 |
| NCAAF | 2022/10/22 19:00 | Southern Illinois v South Dakota | L | 24-27 |
| NCAAF | 2022/10/15 19:00 | Western Illinois v Southern Illinois | W | 7-30 |