Stadium: Manning Field at John L. Guidry Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: Eric Morris
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | W | 21-38 |
| NCAAF | 2021/03/27 16:00 | Incarnate Word v Nicholls State | L | 45-75 |
| NCAAF | 2019/11/02 21:00 | Nicholls State v Incarnate Word | L | 27-23 |
| NCAAF | 2018/10/27 20:00 | Nicholls State v Incarnate Word | L | 48-21 |
| NCAAF | 2017/10/28 19:00 | Incarnate Word v Nicholls State | L | 31-38 |
| NCAAF | 2021/11/06 19:00 | SE Louisiana v Incarnate Word | W | 52-55 |
| NCAAF | 2021/10/30 20:00 | Houston Baptist v Incarnate Word | W | 21-49 |
| NCAAF | 2021/10/23 17:00 | Incarnate Word v McNeese State | L | 20-28 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | W | 21-38 |
| NCAAF | 2021/10/02 23:00 | Incarnate Word v Northwestern State | W | 38-27 |
| NCAAF | 2021/09/25 16:00 | McNeese State v Incarnate Word | W | 0-31 |
| NCAAF | 2021/09/18 23:00 | Incarnate Word v Texas State | W | 42-34 |
| NCAAF | 2021/09/12 00:00 | Prairie View A&M v Incarnate Word | W | 9-40 |
| NCAAF | 2021/11/06 17:00 | Nicholls State v McNeese State | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | Northwestern State v Nicholls State | W | 21-42 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Baptist | W | 44-14 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | L | 21-38 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | L | 58-48 |
| NCAAF | 2021/10/02 20:00 | Houston Baptist v Nicholls State | W | 17-48 |
| NCAAF | 2021/09/25 20:00 | North Alabama Lions v Nicholls State | W | 14-31 |
| NCAAF | 2021/09/11 23:00 | Nicholls State v Lafayette | L | 24-27 |