Face à face
| MLB | 2021/04/20 22:10 | CHI White Sox v CLE Guardians | L | 8-5 |
| MLB | 2021/04/15 18:10 | CLE Guardians v CHI White Sox | W | 4-2 |
| MLB | 2021/04/15 00:10 | CLE Guardians v CHI White Sox | L | 0-8 |
| MLB | 2021/04/14 00:10 | CLE Guardians v CHI White Sox | W | 2-0 |
| MLB | 2021/04/13 00:10 | CLE Guardians v CHI White Sox | L | 3-4 |
| MLB Exhibition | 2021/03/20 20:05 | CLE Guardians v CHI White Sox | L | 2-6 |
| MLB - Entraînement de printemps | 2021/03/06 20:05 | CHI White Sox v CLE Guardians | L | 7-0 |
| MLB | 2020/09/24 22:10 | CHI White Sox v CLE Guardians | W | 4-5 |
Home History
| MLB | 2021/04/28 17:10 | MIN Twins v CLE Guardians | L | 10-2 |
| MLB | 2021/04/27 22:10 | MIN Twins v CLE Guardians | W | 4-7 |
| MLB | 2021/04/26 22:10 | MIN Twins v CLE Guardians | W | 3-5 |
| MLB | 2021/04/25 17:10 | NY Yankees v CLE Guardians | W | 3-7 |
| MLB | 2021/04/24 22:10 | NY Yankees v CLE Guardians | L | 2-1 |
| MLB | 2021/04/23 23:10 | NY Yankees v CLE Guardians | L | 5-3 |
| MLB | 2021/04/22 22:10 | NY Yankees v CLE Guardians | L | 6-3 |
| MLB | 2021/04/20 22:10 | CHI White Sox v CLE Guardians | L | 8-5 |
Away History
| MLB | 2021/04/30 00:45 | DET Tigers v CHI White Sox | W | 0-11 |
| MLB | 2021/04/29 21:10 | DET Tigers v CHI White Sox | W | 1-3 |
| MLB | 2021/04/28 00:10 | DET Tigers v CHI White Sox | L | 5-2 |
| MLB | 2021/04/25 18:10 | TEX Rangers v CHI White Sox | W | 4-8 |
| MLB | 2021/04/24 23:10 | TEX Rangers v CHI White Sox | W | 1-2 |
| MLB | 2021/04/24 00:10 | TEX Rangers v CHI White Sox | W | 7-9 |
| MLB | 2021/04/20 22:10 | CHI White Sox v CLE Guardians | W | 8-5 |
| MLB | 2021/04/19 15:10 | CHI White Sox v BOS Red Sox | L | 4-11 |
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